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Gene Drive: 21st Century Genetic Control of Agricultural and Public Health Pests

Vancouver, Canada

Dr. Andrew Roberts, Deputy Executive Director, delivered the presentation Environmental Risk Assessment of Gene Drive Insects at the Section Symposium: Gene Drive: 21st Century Genetic Control of Agricultural and Public Health Pests, which took place during the 2018 Entomology Society of America Annual Meeting in Vancouver, Canada.

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Environmental Risk Assessment of Genetically Modified Crops and Insects: Lessons Learned from the Past and Next Steps in a Changing World

Vancouver, Canada

Dr. Andrew Roberts, Deputy Executive Director, delivered the presentation The Global Perspective on ERA Regulations for GE Crops and Insects at the Section Symposium: Environmental Risk Assessment of Genetically Modified Crops and Insects: Lessons Learned from the Past and Next Steps in a Changing World, which took place during the 2018 Entomology Society of America Annual Meeting in Vancouver, Canada.

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2nd Asia Forum on Genome Editing

Gangneung, Korea

Dr. Morven McLean, Executive Director, chaired the session Advances in Genome Editing and Related Regulation with Recent GMO Safety Issues in the USA, EU, and Germany at the 2nd Asia Forum on Genome Editing

Read more

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Dr. Andrew Roberts, Deputy Executive Director, delivered the presentation Environmental Risk Assessment of Gene Drive Insects at the Section Symposium: Gene Drive: 21st Century Genetic Control of Agricultural and Public Health Pests, which took place during the 2018 Entomology Society of America Annual Meeting in Vancouver, Canada.

More detailed information about the session is available on the Entomological Society of America website

Agenda

Abstract & Presentation

Agenda

Introductory Remarks
David A. O'Brochta, Foundation for the National Institutes of Health (Organizer)
Blair D. Siegfried, University of Florida (Organizer)
Scott T. O'Neal, Virginia Polytechnic Institute and State University (Moderator)
Peter D. Jensen, Monsanto Company (Moderator)

Natural Selfish Genetic Elements and Gene Drive - Their Relevance to Evolution
Gerald S. Wilkinson, University of Maryland
Kimberly Paczolt, University of Maryland
Josephine Reinhardt, University of New York

Engineered Gene Drives - Types and Mechanisms
Omar Akbari, University of California, San Diego

Gene Drives for Public Health - Modifying Vector Populations
Rebeca Carballar-Lejarazú, University of California, Irvine

Gene Drive Performance - Insights from Modeling
Alun Lloyd, North Carolina State University

Gene Drives for Agricultural Insect Control
Max Scott, North Carolina State University

Ethics, Social, and Community Considerations Raised by Gene Drives
Claudia Emerson and Aaron Roberts, McMaster University

Environmental Risk Assessment of Gene Drive Insects
Andrew F. Roberts, ILSI Research Foundation

Gene Drives for Public Health - Suppressing Vector Populations
Austin Burt, Imperial College of London
Tony Nolan, Imperial College of London

Abstract & Presentation

Environmental Risk Assessment of Gene Drive Insects
Andrew F. Roberts, ILSI Research Foundation

The potential to use gene drive mechanisms to address intractable public health problems caused by vector-borne diseases has been of interest to scientists for decades, but recent advances in molecular biology have brought this idea closer to feasibility and consequently into the public consciousness. To begin discussions in Africa that will facilitate the consideration of potential future use of gene drive technologies to control malaria, the New Partnership for African Development (NEPAD) organized a series of regional consultations taking place in 2016-2018. Drawing from his experience in facilitating problem formulation exercises at these consultations, as well as other sources, I will share some of my own conclusions about the utility (and the necessity) of applying an organized scoping process like problem formulation to better inform the risk assessment process, especially as it relates to new technologies or new uses of technology. I will also review commonly identified assessment endpoints that can provide guidance to future risk assessments for gene drive mosquitoes. These include potential alterations to vectorial capacity that might impact human or animal health, the potential for aquatic larvae to influence water quality, and the potential for harm resulting from altered ecosystem interactions.

Download Presentation

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Dr. Andrew Roberts, Deputy Executive Director, delivered the presentation The Global Perspective on ERA Regulations for GE Crops and Insects at the Section Symposium: Environmental Risk Assessment of Genetically Modified Crops and Insects - Lessons Learned from the Past and Next Steps in a Changing World, which took place during the 2018 Entomoloagy Society of America Annual Meeting in Vancouver, Canada.

More detailed information about the session is available on the Entomological Society of America website.

Agenda

Abstract & Presentation

Agenda

Introductory Remarks
Tony Shelton, Cornell University (Organizer)
Jörg Romeis, Agroscope (Organizer)
Ana Maria Velez, University of Nebraska (Organizer)

Evolution of Environmental Risk Assessment for GM Crops
Paul Jepson, Oregon State University

Assessing the Risk of Bt Crops to Arthropod Natural Enemies: A Tri-Trophic Perspective
Steven Naranjo, USDA - ARS
Tony Shelton, Cornell University
Junce Tian, Zhejiang University
Jörg Romeis, Agroscope
Richard Hellmich, USDA - ARS

Systematically Reviewing Non-Target Effects of Bt Maize on Arthropods in Field Studies: Pitfalls and Opportunities of Meta-Analysis
Michael Meissle, Agroscope
Steven Naranjo, USDA - ARS
Jörg Romeis, Agroscope

Risk Assessment of RNAi and Gene Editing in Pest Management
Ana Velez, University of Nebraska, Lincoln

Gene Drive: An Overview for Pest Management
Timothy Harvey-Samuel, Pirbright Institute

Role of Population Modification in the Malaria Eradication Agenda
Anthony James and Rebeca Carballar-Lejarazú, University of California, Irvine

The US System for Regulating GE Organisms in Agriculture
Lisa Knolhoff, USDA - APHIS

The Global Perspective on ERA Regulations for GE Crops and Insects
Andrew F. Roberts, ILSI Research Foundation

The Cornell-Oxitec Project: The First Release of Self-Limiting Insects in North America
Tony Shelton, Cornell University
Neil Morrison, Oxitec Ltd.

Fall Armyworm in Africa: Can GE Technologies Be Part of the Solution?
Joseph E. Huesing and Regina Eddy, United States Agency for International Development

Biological Control of Human Diseases and Crop Pests with GM Insects
Brad Shurdut, Intrexon Corporation
Neil Morrison, Oxitec Ltd.
Catherine Reavey, Oxitec Ltd.

Managing GM Crop Dominated Landscapes: Case of the Monarch Butterfly
Richard Hellmich, USDA - ARS

Panel Discussion

Abstract & Presentation

The Global Perspective on ERA Regulations for GE Crops and Insects
Andrew F. Roberts, ILSI Research Foundation

Global experience with environmental risk assessment (ERA) for genetically engineered (GE) organisms has focused almost exclusively on considerations for GE crops. Up until now, only a small number of cases featuring a handful of other organisms (including trees, fish, microorganisms and insects) have received regulatory ERA for release to the environment. However, new and emerging technologies are bringing GE insects into the spotlight. This talk will review the current global experience with regulatory ERA of GE insects, identify relevant international treaties (such as the Convention on Biological Diversity and its Cartagena Protocol on Biosafety), and offer some insight on how regulatory ERA for GE insects is likely to move forward as these technologies are deployed around the world.

Download Presentation

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Dr. Morven McLean, Executive Director, chaired the session Advances in Genome Editing and Related Regulation with Recent GMO Safety Issues in the USA, EU, and Germany at the 2nd Asia Forum on Genome Editing held November 1-2 in Gangneung, South Korea. Launched in 2017, the Asia Forum is a unique platform for sharing ideas related to the management of potential risks resulting from genome editing technologies with a focus on Asian countries.

Agenda

November 1, 2018

November 2, 2018

November 1, 2018

Registration and Opening Ceremony

Session 1: Advances in Genome Editing and Related Regulation with Recent GMO Safety Issues in the USA, EU, and Germany

Chair: Morven McLean

Speaker - USA:
Ibrahim M. Shaqir, USDA APHIS Biotechnology Regulatory Services

Speaker - EU & Germany:
Jens Kahrmann, Federal Office of Consumer Protection and Food Safety, Department of Genetic Engineering

Session 2: Advances in Genome Editing and Related Regulation with Recent GMO Safety Issues in China and India

Chair: Huy Ham Le

Speakers - China:
Yue Jiao, Development Center for Science and Technology, Ministry of Agriculture and Rural Affairs
Gang Wu, Supervision and Test Center (Wuhan) for Environmental Safety of Genetically Modified Organisms, MARA China & Oil Crops Research Institute, CAAS

Speakers - India:
A. K. Mehta, Ministry of Environment, Forest and Climate Change
Vibha Ahuja, Biotech Consortium India Limited

Session 3: Advances in Genome Editing and Related Regulation with Recent GMO Safety Issues in Bangladesh, Cambodia, the Philippines, and Vietnam

Chair: Letchu Rama

Speaker - Bangladesh:
M. Imdadul Hoque, Department of Botany, Faculty of Biological Science, University of Dhaka

Speaker - Cambodia:
Pisey Oum, Ministry of Environment

Speaker - The Philippines:
Julieta Estacio, National Committee on Biosafety of the Philippines

Speaker - Vietnam:
Huy Ham Le, Institute of Agricultural Genetics

Comprehensive Discussion
Chairs: Homin Jang & Heidi Michell

Welcome Reception

November 2, 2018

Session 4: Advances in Genome Editing and Related Regulation with Recent GMO Safety Issues in Japan and Australia

Chair: Ibrahim M. Shaqir

Speaker - Japan:
Masashi Tachikawa, Graduate School of Environmental Studies, Nagoya University

Speaker - Australia:
Heidi Mitchell, Plant Evaluation Section, Office of the Gene Technology Regulator, Australian Government Department of Health

Session 5: Advances in Genome Editing and Related Regulation with Recent GMO Safety Issues in Malaysia and Korea

Chair: Imdadul Hoque

Speakers - Malaysia:
Raimi Rosmin, Department of Biosafety, Ministry of Natural Resources and Environment
Mohd Faiz Foong Abdullah, Faculty of Applied Sciences, Universiti Teknologi Mara

Speaker - Korea:
Representative from ToolGen
Ancheol Jang, Biosafety Division, National Institute of Agricultural Science/Rural Development Administration

Comprehensive Discussion
Chairs: Homin Jang & Vibha Ahuja

Closing Remarks

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Dr. Andrew Roberts, Deputy Executive Director, delivered the presentation Environmental Risk Assessment of Gene Drive Insects at the Section Symposium: Gene Drive: 21st Century Genetic Control of Agricultural and Public Health Pests, which took place during the 2018 Entomology Society of America Annual Meeting in Vancouver, Canada.

More detailed information about the session is available on the Entomological Society of America website

Agenda

Abstract & Presentation

Agenda

Introductory Remarks
David A. O'Brochta, Foundation for the National Institutes of Health (Organizer)
Blair D. Siegfried, University of Florida (Organizer)
Scott T. O'Neal, Virginia Polytechnic Institute and State University (Moderator)
Peter D. Jensen, Monsanto Company (Moderator)

Natural Selfish Genetic Elements and Gene Drive - Their Relevance to Evolution
Gerald S. Wilkinson, University of Maryland
Kimberly Paczolt, University of Maryland
Josephine Reinhardt, University of New York

Engineered Gene Drives - Types and Mechanisms
Omar Akbari, University of California, San Diego

Gene Drives for Public Health - Modifying Vector Populations
Rebeca Carballar-Lejarazú, University of California, Irvine

Gene Drive Performance - Insights from Modeling
Alun Lloyd, North Carolina State University

Gene Drives for Agricultural Insect Control
Max Scott, North Carolina State University

Ethics, Social, and Community Considerations Raised by Gene Drives
Claudia Emerson and Aaron Roberts, McMaster University

Environmental Risk Assessment of Gene Drive Insects
Andrew F. Roberts, ILSI Research Foundation

Gene Drives for Public Health - Suppressing Vector Populations
Austin Burt, Imperial College of London
Tony Nolan, Imperial College of London

Abstract & Presentation

Environmental Risk Assessment of Gene Drive Insects
Andrew F. Roberts, ILSI Research Foundation

The potential to use gene drive mechanisms to address intractable public health problems caused by vector-borne diseases has been of interest to scientists for decades, but recent advances in molecular biology have brought this idea closer to feasibility and consequently into the public consciousness. To begin discussions in Africa that will facilitate the consideration of potential future use of gene drive technologies to control malaria, the New Partnership for African Development (NEPAD) organized a series of regional consultations taking place in 2016-2018. Drawing from his experience in facilitating problem formulation exercises at these consultations, as well as other sources, I will share some of my own conclusions about the utility (and the necessity) of applying an organized scoping process like problem formulation to better inform the risk assessment process, especially as it relates to new technologies or new uses of technology. I will also review commonly identified assessment endpoints that can provide guidance to future risk assessments for gene drive mosquitoes. These include potential alterations to vectorial capacity that might impact human or animal health, the potential for aquatic larvae to influence water quality, and the potential for harm resulting from altered ecosystem interactions.

Download Presentation

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